Table 1.

Reported adverse events, multiple dose I3C, and placebo

Adverse eventPlacebo400 mg I3C800 mg I3C
Abdominal discomfort, bloating, nausea, vomiting6 (35)7 (41)3 (18)
Asthma1 (6)
Breast tenderness3 (18)
Chest pain1 (6)
Constipation2 (12)
Diarrhea/loose stools2 (12)1 (6)
Dizziness1 (6)1 (6)1 (6)
Headache3 (18)1 (6)2 (12)
Musculoskeletal complaints1 (6)4 (24)2 (12)
Rash3 (18)1 (6)
Sciatic nerve pain1 (6)
Sharp pain behind right ear1 (6)
Upper respiratory symptoms1 (6)3 (18)4 (24)
  • NOTE: Values denote the number of individuals who complained of a class of adverse events during each dosing period of the study followed by the percentage of all subjects who expressed that complaint. The total number of subjects was 17.