Table 1.

Analyses of human leukocyte antigen (HLA) and TNFb microsatellite variants previously associated with malignant glioma and related diseases in various cohorts

Genetic variantsReported associationDistribution, {n (%)} in:
ORP*
155 Cases157 Controls
A24Positive24 (15.5)25 (15.9)0.970.92
A*25Positive6 (3.9)8 (5.1)0.750.60
B*27Positive11 (7.1)11 (7.0)1.010.97
DRB1*15Positive39 (25.2)39 (24.8)1.020.95
DRB1*07Negative34 (21.9)38 (24.2)0.880.63
Cw*06-DRB1*07Negative13 (8.4)11 (7.0)1.220.65
TNFb allele 4 (b4) hmz§Positive33 (21.3)23 (14.6)1.580.13
  • * Based on maximum likelihood Chi-square tests.

  • From a study of 42 Japanese patients (39).

  • From a study of 65 German patients (41).

  • § Hmz, homozygosity, from a study of 48 Italian patients (40).