Table 1.

Allele frequencies by clinical subgroup for SNPs in candidate genes

GeneChromosomeSNPPosition*Major>minor alleleMinor allele frequency in
Affected menUnaffected menP
CYP1710q24rs619824−15,891C>A0.410.460.068
CYP1915q21rs11636639−67,703T>G0.420.430.614
CYP11A15q25rs2277602−37,511C>A0.320.320.803
LHB19q13rs753307−1,864C>T0.470.450.448
  • * Base pair position from the transcription start site of each gene according to the human reference sequence (UCSC Genome Browser, Build 35, May 2004).

  • Calculated by treating all men as unrelated subjects (i.e., unadjusted for the within-family correlation).

  • Within intron 1.