Table 4.

Relationship between combined MTHFR genotypes and MSI by folate intake status

Combined MTHFR genotypesTotal folate (μg)MSIMSSOR* (95% CI)
(A) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with high folate intake
    MTHFR 677MTHFR 1298
    CCAA≥400823Reference
    CCAC/CC≥4003440.09 (0.01, 0.59)
    CT/TTAA≥4003280.13 (0.02, 0.85)
    CT/TTAC/CC≥400015ND
(B) ORs and 95% CIs for the association between combined MTHFR genotypes and MSI among subjects with low folate intake
    MTHFR 677MTHFR 1298
    CCAA<400664Reference
    CCAC/CC<40012621.47 (0.43-4.99)
    CT/TTAA<4005570.68 (0.16-2.78)
    CT/TTAC/CC<4003171.20 (0.20-7.32)
  • Abbreviation: ND, not determined.

  • * Adjusted for age, race, tumor location, smoking status, total calcium intake, and vitamin/mineral supplement use.