Table 3.

Adjusted ORs and 95% CIs for MSI in relation to MTHFR genotypes and total, dietary, and supplemental folate

GenotypeTotal folate (μg)MSIMSSOR* (95% CI)Dietary folate (μg)MSIMSSOR* (95% CI)Supplemental folate useMSIMSSOR* (95% CI)
MTHFR 1298
    AA≥4001163Reference≥275589ReferenceYes1058Reference
    AC/CC≥4003730.18 (0.04-0.73)≥27510751.63 (0.49-5.44)Yes1530.10 (0.01-0.81)
    AA<400121470.51 (0.16-1.62)<275181212.46 (0.79-7.67)No131520.62 (0.18-2.11)
    AC/CC<40016940.83 (0.26-2.64)<2759921.17 (0.33-4.20)No181140.82 (0.24-2.76)
MTHFR 677
    CC≥4001276Reference≥2751596ReferenceYes864Reference
    CT/TT≥4003580.29 (0.07-1.17)≥2752660.11 (0.02-0.52)Yes3460.51 (0.12-2.23)
    CC<400211560.92 (0.33-2.59)<275181360.67 (0.27-1.68)No251681.23 (0.34-4.41)
    CT/TT<4008850.53 (0.16-1.79)<2759770.72 (0.26-2.00)No8970.54 (0.13-2.34)
  • * Adjusted for age, race, tumor location, smoking status, total calcium intake, and vitamin/mineral supplement use.