Table 1.

General characteristics of colon cancer cases and associations with MSI

MSS, n = 437 (%)MSI, n = 49 (%)OR (95% CI)
Age (median, 65 y)
    <65212 (49)17 (35)Reference
    ≥65225 (51)32 (65)1.77 (0.96-3.290)
Gender
    Female212 (49)29 (59)Reference
    Male225 (51)20 (41)0.65 (0.36-1.18)
Race
    Blacks204 (47)14 (29)Reference
    Whites233 (53)35 (71)2.19 (1.14-4.18)
Family history
    No350 (80)35 (71)Reference
    Yes87 (20)14 (29)1.61 (0.83-3.12)
Location of tumor
    Distal165 (45)8 (17)Reference
    Proximal205 (55)38 (83)3.82 (1.74-8.42)
Stage of cancer at time of diagnosis
    Local145 (39)17 (39)Reference
    Regional210 (59)26 (59)1.06 (0.55-2.02)
    Distant41 (2)1 (2)0.21 (0.03-1.61)
Alcohol (category of use)
    None306 (71)27 (56)Reference
    Lower half55 (13)8 (17)1.65 (0.71-3.82)
    Upper half73 (17)13 (27)2.02 (0.99-4.10)
Smoking status
    Never184 (42)9 (19)Reference
    Former184 (42)26 (54)2.89 (1.32-6.33)
    Current67 (15)13 (27)3.97 (1.62-9.70)
NSAID use during past 5 y
    Never48 (11)10 (21)Reference
    Occasionally177 (40)23 (48)0.62 (0.28-1.40)
    Frequently212 (49)15 (31)0.34 (0.14-0.80)
Total calcium intake
    Quartile 1113 (26)7 (15)Reference
    Quartile 2109 (25)12 (25)1.78 (0.68-4.68)
    Quartile 3105 (24)16 (33)2.46 (0.97-6.22)
    Quartile 4107 (25)13 (27)1.96 (0.75-5.10)
Vitamin/supplement use
    No/occasional264 (61)29 (62)Reference
    Regularly166 (39)18 (38)0.99 (0.53-1.83)