Table 1.

Demographic and tumor characteristics and association of a nevus with cutaneous malignant melanoma (N = 932)

CharacteristicnN−* (%)nN+* (%)ORcrude (95% CI)ORadj (95% CI)
Study center
    Ontario240 (63)142 (37)1.01.0
    British Columbia66 (63)38 (37)1.0 (0.6-1.5)1.0 (0.6-1.5)
    New South Wales287 (64)159 (36)0.9 (0.7-1.2)1.0 (0.7-1.3)
    P0.900.99
Sex
    Female293 (66)150 (34)1.01.0
    Male300 (61)189 (39)1.2 (0.9-1.6)1.4 (1.0-1.8)
    P0.130.03
Age
    <4084 (58)60 (42)1.01.0
    40-54165 (59)117 (42)1.0 (0.7-1.5)0.9 (0.6-1.4)
    55-69178 (64)103 (37)0.8 (0.5-1.2)0.7 (0.5-1.1)
    70+166 (74)59 (26)0.5 (0.3-0.8)0.5 (0.3-0.7)
    Ptrend0.00050.0001
Ethnicity
    British349 (65)191 (35)1.01.0
    Other Northern European55 (64)31 (36)1.0 (0.6-1.7)1.0 (0.6-1.7)
    Southern/Eastern European24 (52)22 (48)1.7 (0.9-3.1)1.6 (0.8-2.9)
    Mixed120 (65)66 (35)1.0 (0.7-1.4)1.0 (0.7-1.4)
    Other/Don't know34 (59)24 (41)1.3 (0.7-2.2)1.2 (0.7-2.2)
    P0.990.99
Breslow depth (mm)
    ≤0.75286 (58)204 (42)1.01.0
    0.76-1.50175 (67)86 (33)0.7 (0.5-0.9)0.7 (0.5-0.9)
    1.51-4.00104 (71)42 (29)0.6 (0.4-0.9)0.6 (0.4-0.9)
    >4.0028 (80)7 (20)0.4 (0.2-0.8)0.4 (0.2-0.8)
    Ptrend0.00080.0009
Histologic subtype
    SSM388 (57)288 (43)1.01.0
    NM69 (72)27 (28)0.5 (0.3-0.8)0.7 (0.4-1.2)
    LMM77 (88)11 (13)0.2 (0.1-0.4)0.2 (0.1-0.4)
    NOS/Other59 (83)12 (17)0.3 (0.2-0.5)0.3 (0.2-0.7)
    P<0.0001<0.0001
  • Abbreviations: Adj, adjusted; Ptrend, P value, test of trend; SSM, superficial spreading melanoma; NM, nodular melanoma; LMM, lentigo maligna melanoma; NOS, not otherwise specified.

  • * Counts may not sum to the total number of study subjects due to missing data.

  • Adjusted for study center, sex and age.

  • Adjusted for study center, sex, age and Breslow thickness.