Table 6.

Breast cancer odds ratios (95% confidence intervals) by ER and PR status and CYP1A2*F genotype

n*AAACCCP
ER negative205/1,3701.00.8 (0.6-1.1)0.7 (0.4-1.2)0.08
ER positive703/1,3701.00.9 (0.8-1.1)0.8 (0.6-1.2)0.26
PR negative269/1,3701.00.9 (0.7-1.1)0.6 (0.4-1.1)0.08
PR positive605/1,3701.00.9 (0.7-1.1)0.9 (0.6-1.3)0.41
ER/PR negative165/1,3701.00.8 (0.5-1.1)0.5 (0.3-1.1)0.03
ER/PR positive562/1,3701.00.9 (0.8-1.2)0.9 (0.6-1.3)0.41
  • NOTE: Adjusted by logistic regression for age at blood draw, race/ethnicity, age at menarche, parity and age at first birth.

  • * No. cases/no. controls; 431 cases had missing ER status and 465 cases had missing PR status.

  • P value for gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively. The P value for comparison of gene dosage effects between the ER/PR-negative and ER/PR-positive groups by polytomous logistic regression was not statistically significant (P = 0.13).