Table 5.

Joint effects of CYP1A2*1F and CYP1A1*2A, CYP1B1 Leu432Val, AHRArg554Lys, CYP3A4*1B, COMTVal158Met and SULT1A1Arg213His on breast cancer risk

AA
AC
CC
n*OR (95% CI)nOR (95% CI)nOR (95% CI)
CYP1A1*2A
    TT279/2241.0375/3760.8 (0.6-1.0)82/1120.7 (0.5-1.0)
    TC259/2740.9 (0.7-1.1)220/2360.8 (0.6-1.1)6/100.5 (0.2-1.3)
    CC92/1070.8 (0.6-1.1)8/80.7 (0.3-2.0)1/0
    Pinteraction0.64
CYP1B1 Leu432Val
    LL274/2371.0267/2370.8 (0.6-1.1)35/330.9 (0.5-1.5)
    LV240/2470.9 (0.7-1.1)211/2250.8 (0.6-1.1)35/470.6 (0.4-1.1)
    VV116/1210.9 (0.7-1.3)125/1580.8 (0.6-1.1)19/420.5 (0.3-0.9)
    Pinteraction0.75
AHR
    RR368/3751.0303/3180.9 (0.7-1.1)40/540.8 (0.5-1.2)
    RL206/1681.3 (1.0-1.7)223/2261.0 (0.7-1.3)30/540.6 (0.4-1.0)
    LL56/620.8 (0.6-1.3)77/760.9 (0.7-1.4)19/141.4 (0.7-2.8)
    Pinteraction0.13
CYP3A4*1B
    AA537/4611.0469/4390.8 (0.7-1.0)63/760.7 (0.5-1.0)
    AG67/1060.8 (0.5-1.1)81/1200.8 (0.6-1.2)13/260.6 (0.3-1.2)
    GG26/380.9 (0.5-1.6)53/611.1 (0.7-1.8)13/200.8 (0.4-1.8)
    Pinteraction0.54
COMT Val158Met
    Val/Val242/2481.0239/2450.9 (0.7-1.2)33/490.7 (04.-1.1)
    Val/Met300/2641.1 (0.8-1.4)273/2810.9 (0.7-1.1)41/590.7 (0.5-1.1)
    Met/Met88/930.9 (0.6-1.3)91/940.8 (0.6-1.2)15/141.0 (0.5-2.2)
    Pinteraction0.71
SULT1A1 Arg213His
    Arg/Arg376/3351.0364/3560.9 (0.7-1.1)51/820.6 (0.4-0.9)
    Arg/His195/2190.8 (0.6-1.1)192/2160.8 (0.6-1.0)30/360.8 (0.5-1.4)
    His/His59/511.0 (0.7-1.6)47/480.8 (0.5-1.3)8/42.1 (0.6-7.2)
    Pinteraction0.22
  • Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * No. cases/no. controls. Numbers of subjects vary due to missing information.

  • OR (95% CIs) adjusted for age at blood draw, age at menarche, parity and age at first birth.

  • P value derived from a likelihood ratio test comparing a model with main effects for the CYP1A2*1F genotype and the risk factor, and a model with main effects and interaction terms.