Table 2.

Breast cancer odds ratios (95% confidence intervals) by genotype

Genotypen*Odds ratio (95% confidence interval)Odds ratio (95% confidence interval)
CYP1A1*2A
    TT743/7221.01.0
    TC493/5301.0 (0.9-1.2)1.0 (0.8-1.2)
    CC103/1181.0 (0.8-1.4)1.0 (0.6-1.4)
    P0.78§0.85
CYP1A2*1F
    AA640/6171.01.0
    AC608/6270.9 (0.7-1.0)0.9 (0.7-1.0)
    CC91/1250.8 (0.6-1.0)0.7 (0.5-1.0)
    P0.030.03
CYP1B1 Leu432Val
    LL581/5161.01.0
    LV495/5251.0 (0.8-1.1)0.9 (0.8-1.1)
    VV263/3290.9 (0.7-1.2)0.9 (0.7-1.1)
    P0.470.32
AHR Arg554Lys
    RR721/7561.01.0
    RL463/4561.1 (0.9-1.3)1.1 (0.9-1.3)
    LL155/1581.0 (0.8-1.3)1.0 (0.7-1.3)
    P0.620.75
CYP3A4*1B
    AA1,080/9941.01.0
    AG164/2540.9 (0.7-1.2)0.9 (0.7-1.2)
    GG95/1221.1 (0.6-1.6)1.1 (0.8-1.7)
    P0.660.68
COMT Val158Met
    Val/Val519/5501.01.0
    Val/Met624/6141.0 (0.9-1.2)1.0 (0.8-1.2)
    Met/Met196/2060.9 (0.7-1.2)0.9 (0.7-1.2)
    P0.710.64
SULT1A1 Arg213His
    Arg/Arg801/7821.01.0
    Arg/His424/4840.9 (0.7-1.0)0.9 (0.7-1.0)
    His/His114/1041.1 (0.8-1.5)1.1 (0.8-1.5)
    P0.630.63
  • * No. cases/No. controls.

  • Odds ratios adjusted for age at blood draw and race/ethnicity.

  • Odds ratios further adjusted for age at menarche, parity, and age at first birth.

  • § P value for gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively.