Table 2.

Risk of left-sided advanced colorectal adenoma, by smoking history, broccoli intake, and genotype

Controls (n = 777)
Cases (n = 772)
OR (95% CI)*
n (%)n (%)
Smoking status
    Never315 (40.8)260 (33.8)1.0
    Former, quit ≥10 y302 (39.2)272 (35.4)1.1 (0.9-1.4)
    Current and recent quitters (<10 y)111 (14.4)198 (25.8)2.4 (1.8-3.1)
    Ptrend*,<0.001
    Ever419 (57.1)473 (64.5)1.4 (1.2-1.8)
    Cigar/pipe43 (5.6)39 (5.1)1.2 (0.7-1.9)
GSTM1
    +/+37 (5.4)62 (9.4)1.0
    +/−276 (40.1)249 (37.6)0.6 (0.4-0.9)
    −/−376 (54.6)352 (53.1)0.6 (0.4-0.9)
    +/− and −/− combined652 (94.7)601 (90.7)0.6 (0.4-0.9)
GSTT1
    +/+241 (34.3)221 (32.0)1.0
    +/−343 (48.9)340 (49.3)1.1 (0.9-1.4)
    −/−118 (16.8)129 (18.7)1.2 (0.9-1.7)
    +/− and −/−461 (65.7)469 (68.0)1.1 (0.9-1.4)
GSTP1-I105V
    AA317 (45.4)282 (41.4)1.0
    AG293 (42.0)314 (46.1)1.2 (1.0-1.5)
    GG88 (12.6)85 (12.5)1.1 (0.8-1.6)
    Ptrend0.2
GSTP1-A114V
    CC596 (83.5)591 (84.4)1.0
    CT114 (16.0)103 (14.7)0.9 (0.7-1.2)
    TT4 (0.6)6 (0.9)1.6 (0.4-5.7)
    Ptrend0.8
  • * Adjusted for age, race, and gender.

  • Smoking pipe and cigar and former smokers combined were not included in the trends estimation.