Table 1.

Description of subjects enrolled in the nested case-control study of colorectal adenoma within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

CharacteristicsControls (n = 777)
Cases (n = 772)
Pχ2
n (%)n (%)
Sexmale536 (69.0)535 (69.3)0.9
female241 (31.0)237 (30.7)
Age at interview55-59363 (46.7)257 (33.3)<0.0001
60-64200 (25.7)244 (31.6)
65-69140 (18.0)172 (22.3)
70-7474 (9.5)99 (12.8)
RaceWhite729 (93.8)725 (93.9)1.0
Black23 (3.0)22 (2.9)
others*25 (3.2)25 (3.2)
First-degree family member with history of colorectal cancerno707 (91.0)675 (87.4)0.02
yes70 (9.0)97 (12.6)
Level of education (y)≤1150 (6.4)72 (9.3)0.001
12 or high school176 (22.7)191 (24.8)
some college247 (31.8)276 (35.8)
college and above303 (39.1)232 (30.1)
Body mass index at interview<18.52 (0.3)5 (0.7)0.3
≥18.5 to <25219 (28.2)200 (25.9)
≥25 to <30357 (46.0)349 (45.2)
≥30188 (24.2)215 (27.9)
Pathologic characteristics of adenoma(s)
    Size (cm)<1200 (25.9)
≥1§572 (74.1)
Number1527 (68.3)
>1245 (31.7)
Histologynonadvanced283 (36.7)
advanced489 (63.3)
  • * Hispanic (0.9%), Asian (1.7%), Pacific Islander (0.4%), and American Indian native (0.3%).

  • Post-high school and some college education.

  • Adenoma size <1 cm, with high-grade dysplasia or villous elements.

  • § Two hundred and eighty-nine subjects (50.5%) with adenoma size ≥1 cm, with high-grade dysplasia or villous elements.

  • Adenomas with high-grade dysplasia or villous elements.