Table 1.

Number of cases and controls, allele frequencies, and quality score of the studies included in the meta-analysis

First author year (reference)CountryCancerRacial descentGenotyped subjects, codon 399 (codon 194) [codon 280]Allele frequency among controls, codon 399 (codon 194) [codon 280]
Hao 2004 (52)ChinaEsophageal cancerAsian[415/480][0.104]
Forsti 2004 (49)FinlandBreast cancerMixed ethnicity223/298 (223/298)0.320 (0.027)
Figueiredo 2004 (48)CanadaBreast cancerMixed ethnicity402/4020.372
Sanyal 2004 (47)SwedenBladder cancerEuropean311/2460.317
Harms 2004 (46)AmericanLung cancerEuropean110/1190.298
Matsuo 2004 (45)JapanMalignant lymphomasAsian369/5000.243
Shu 2003 (44)ChinaBreast cancerAsian1,088/1,1820.273
Han 2003 (43)AmericanBreast cancerMixed ethnicity986/1,337 (998/1,369)0.362 (0.066)
Shen 2003 (42)ItalyBladder cancerEuropean201/2140.341
Smith 2003 (41)AmericanBreast cancerEuropean251/267 (246/266)0.339 (0.047)
Moullan 2003 (40)FranceBreast cancerMixed ethnicity254/312 (254/312) [254/312]0.359 (0.069) [0.046]
Varzim 2003 (39)PortugalLarynx cancerEuropean88/178 (88/178)0.326 (0.051)
Cho 2003 (38)ChinaNasopharyngeal cancerAsian334/2820.268
Yu 2003 (37)ChinaHepatocellular cancerAsian577/3890.256
Zhou 2003 (36)AmericanLung cancerEuropean1,091/1,2400.335
Misra 2003 (35)FinlandLung cancerMixed ethnicity315/313 [309/302]0.300 [0.070]
Smith 2003 (34)AmericanBreast cancerEuropean162/300 (162/301)0.353 (0.063)
Van Gils 2002 (33)AmericanProstate cancerMixed ethnicity76/182 (76/182) [76/182]0.363 (0.088) [0.049]
Seedhouse 2002 (32)EnglandMyeloblastic leukemiaEuropean167/178 (126/87)0.478 (0.063)
Lee 2002 (31)KoreaGastric cancerAsian190/172 (190/172) [190/172]0.253 (0.331) [0.102]
Duell 2002 (30)AmericanPancreatic adenocarcinomaEuropean250/8320.319
Asian17/510.265
African26/360.153
Chen 2002 (29)ChinaLung cancerAsian103/99 (103/102)0.273 (0.245)
Xing 2002 (28)ChinaEsophageal cancerAsian433/524 (433/524)0.281 (0.288)
Kim 2002 (27)KoreaBreast cancerAsian205/205 (205/205)0.315 (0.341)
Olshan 2002 (26)AmericanHead and neck cancerEuropean98/161 (98/161)0.360 (0.081)
Park 2002 (25)KoreaLung cancerAsian192/1350.222
Nelson 2002 (24)EnglandNonmelanoma skin cancerEuropean745/4310.379
David-Beabes 2001 (23)AmericanLung cancerEuropean180/461 (180/461)0.361 (0.059)
African154/243 (154/243)0.181 (0.082)
Lee 2001 (22)ChinaEsophageal cancerAsian105/264 (105/264) [105/264]0.295 (0.299) [0.102]
Matullo 2001 (6)ItalyBladder cancerMixed ethnicity124/840.387
Duell 2001 (21)AmericanBreast cancerEuropean386/381 (233/221)0.362 (0.075)
African253/266 (155/160)0.135 (0.063)
Stern 2001 (20)AmericanBladder cancerEuropean214/197 (213/197) [214/195]0.365 (0.086) [0.044]
African19/13 (19/13) [19/13]0.154 (0.115) [0.000]
Ratnasinghe 2001 (19)ChinaLung cancerAsian107/208 (108/210) [106/209]0.245 (0.348) [0.077]
Divine 2001 (18)AmericanLung adenocarcinomaEuropean129/710.296
Hispanic American43/720.347
Winsey 2000 (17)EnglandMalignant melanomaEuropean125/211 (125/211)0.365 (0.085)
Abdel-Rahman 2000 (16)EgyptColorectal cancerAfrican48/48 (48/48)0.135 (0.052)
Shen 2000 (15)ChinaGastric adenocarcinomaAsian188/166 (188/166)0.256 (0.346)
Sturgis 1999 (14)AmericanHead and neck cancerMixed ethnicity203/424 (203/424)0.341 (0.072)
  • NOTE: Mixed ethnicity: Forsti 2004, unknown; Figueiredo 2004, mostly European; Han 2003, mostly European; Moullan 2003, unknown; Misra 2003, unknown; van Gils 2002, European and African American; Matullo 2001, unknown; Sturgis 1999, Non-Hispanic White, Mexican-American, and African American.