Table 4.

Mean ± SE values of measures of adult obesity among Hispanic and non-Hispanic White women, by IGF1, IGFBP3, IRS1, IRS2, and VDR genotypes

GenotypeBMI, kg/m2
Waist, cm
WHR
HispanicNon-Hispanic WhiteHispanicNon-Hispanic WhiteHispanicNon-Hispanic White
IGF1 CA repeat
    19/1929.9 ± 0.527.7 ± 0.392.2 ± 1.186.6 ± 0.60.841 ± 0.0050.802 ± 0.003
    19/other29.5 ± 0.527.5 ± 0.292.3 ± 1.287.0 ± 0.60.851 ± 0.0050.813 ± 0.003
    Other/other29.3 ± 0.827.1 ± 0.491.8 ± 1.885.8 ± 1.10.852 ± 0.0080.808 ± 0.005
    P*0.480.150.870.820.130.03
IGFBP3 −202 C > A
    CC29.6 ± 0.527.4 ± 0.391.8 ± 1.286.6 ± 0.70.846 ± 0.0050.809 ± 0.004
    AC29.4 ± 0.527.8 ± 0.291.6 ± 1.187.3 ± 0.60.846 ± 0.0050.809 ± 0.003
    AA30.7 ± 0.827.4 ± 0.394.2 ± 1.985.7 ± 0.80.852 ± 0.0080.803 ± 0.004
    P*0.410.900.410.540.190.17
IRS1 G972R
    GG29.7 ± 0.427.5 ± 0.292.3 ± 0.886.6 ± 0.50.849 ± 0.0040.808 ± 0.002
    GR or RR29.6 ± 0.928.0 ± 0.490.3 ± 2.288.1 ± 1.10.828 ± 0.0100.807 ± 0.005
    P*0.940.320.360.170.020.92
IRS2 G1057D
    GG29.4 ± 0.527.7 ± 0.390.8 ± 1.286.9 ± 0.60.843 ± 0.0050.809 ± 0.003
    GD29.8 ± 0.527.7 ± 0.292.8 ± 1.186.7 ± 0.60.849 ± 0.0050.806 ± 0.003
    DD29.7 ± 0.727.0 ± 0.492.5 ± 1.786.3 ± 1.00.845 ± 0.0070.808 ± 0.005
    P*0.680.240.310.590.600.63
VDR BsmI
    bb30.1 ± 0.427.6 ± 0.393.1 ± 1.086.6 ± 0.70.848 ± 0.0040.806 ± 0.003
    bB29.4 ± 0.527.5 ± 0.291.4 ± 1.286.8 ± 0.60.845 ± 0.0050.808 ± 0.003
    BB27.8 ± 1.127.5 ± 0.488.5 ± 2.586.8 ± 0.90.840 ± 0.0110.810 ± 0.005
    P*0.040.800.060.810.460.47
VDR FokI
    FF29.4 ± 0.627.4 ± 0.391.1 ± 1.386.1 ± 0.70.840 ± 0.0060.806 ± 0.003
    Ff29.8 ± 0.527.6 ± 0.292.2 ± 1.187.1 ± 0.60.843 ± 0.0050.811 ± 0.003
    ff29.3 ± 0.727.9 ± 0.492.5 ± 1.787.1 ± 1.10.864 ± 0.0070.800 ± 0.005
    P*0.990.350.420.230.010.77
  • NOTE: Means are adjusted for age and study center, with BMI also adjusted for height, and WHR adjusted for BMI. The numbers of subjects by genotype are shown in Table 2.

  • * P value from test for trend in anthropometric variable according to number of variant alleles.

  • Significant evidence of heterogeneity of genotype effect by race: IRS1 and WHR, P = 0.05; VDR FokI and WHR, P = 0.03.