Table 3.

Mean ± SE values of measures of growth among Hispanic and non-Hispanic White women, by IGF1, IGFBP3, IRS1, IRS2, and VDR genotypes

GenotypeBirthweight, kg
Height, m
HispanicNon-Hispanic WhiteHispanicNon-Hispanic White
IGF1 CA repeat
    19/193.07 ± 0.073.23 ± 0.041.563 ± 0.0051.626 ± 0.003
    19/other3.10 ± 0.073.24 ± 0.041.566 ± 0.0051.628 ± 0.003
    Other/other3.19 ± 0.123.14 ± 0.081.566 ± 0.0071.625 ± 0.005
    P*0.390.620.690.91
IGFBP3 −202 C > A
    CC3.05 ± 0.073.19 ± 0.051.557 ± 0.0051.628 ± 0.003
    AC3.14 ± 0.073.23 ± 0.041.568 ± 0.0051.625 ± 0.003
    AA3.11 ± 0.123.29 ± 0.061.583 ± 0.0081.627 ± 0.004
    P*0.470.180.0030.79
IRS1 G972R
    GG3.10 ± 0.053.23 ± 0.031.564 ± 0.0041.626 ± 0.002
    GR or RR3.10 ± 0.143.24 ± 0.071.576 ± 0.0091.630 ± 0.005
    P*0.990.970.210.42
IRS2 G1057D
    GG3.21 ± 0.083.19 ± 0.041.566 ± 0.0051.628 ± 0.003
    GD3.05 ± 0.073.26 ± 0.041.563 ± 0.0051.624 ± 0.003
    DD3.05 ± 0.103.27 ± 0.071.574 ± 0.0071.632 ± 0.005
    P*0.130.230.530.89
VDR BsmI
    bb3.09 ± 0.063.26 ± 0.041.563 ± 0.0041.628 ± 0.003
    bB3.11 ± 0.073.19 ± 0.041.568 ± 0.0051.629 ± 0.003
    BB3.19 ± 0.163.31 ± 0.071.564 ± 0.0111.618 ± 0.004
    P*0.550.970.610.06
VDR FokI
    FF3.07 ± 0.073.24 ± 0.041.566 ± 0.0051.628 ± 0.003
    Ff3.05 ± 0.073.24 ± 0.041.566 ± 0.0051.626 ± 0.003
    ff3.14 ± 0.093.17 ± 0.071.562 ± 0.0071.623 ± 0.005
    P*0.590.440.710.29
  • NOTE: Means are adjusted for age and study center. The numbers of subjects by genotype category are shown in Table 2.

  • * P value from test for trend in anthropometric variable according to number of variant alleles.

  • Significant evidence of heterogeneity of genotype effect by race, P = 0.003.