Table 1.

Characteristics of studies on GST and risk of brain tumors

Study (first author)Year of publicationCountryTypes of brain tumorCases (n)*Controls (n)*MatchingMatching variablesSource of controlGST M1GST T1GSTP I105VGSTP A104VGlioma histopathologic subgroups studiedGene- gene interactionGene- environment interaction
Pinarbasi2005TurkeyGlioma and meningiomaGlioma, 31; meningioma, 23153FrequencyAge, genderHospitalXXXNoneNoneM1, T1 and P1 I105V with smoking
Wrensch2004U.S.A.Glioma458428FrequencyAge, race, genderPopulationXXXX(a) GBM versus others; (b) GBM, A and AA, ODG and OA, othersP53 + M1, T1, P1None
Butler2003U.S.A.Glioma325579FrequencyAge, genderPopulationXXXGBM, A, ODGNoneGST variants with living on farm status, smoking and pesticides used
De Roos2003U.S.A.Glioma, meningioma, and acoustic neuromaGlioma, 422; meningioma, 172; acoustic neuroma, 79604FrequencyHospital, age, gender, race, distance from home to hospitalHospitalXXXXGBM, AA Other A, ODG, Mixed OAI105V + A114V; I105 V + CYP2E1; I105V + T1; T1 + CYP2E1None
Ezer2002U.S.A.Glioma and neuroepithelial tumorsGlioma, 141; neuroepithelial tumors, 76653-1,709§NoneNonePopulationXXXXAA, ODG, OANoneNone
Kondrateva1999RussiaGlioma54103NoneNoneHospital-healthyXHigh versus low grade gliomaM1 + L-MYCNone
Trizna1998U.S.A.Glioma9090FrequencyAge, race, genderHospital-healthyXXNoneT1 + NAT2None
Elexpuru-Camiruaga1995Great BritainGlioma and meningiomaGlioma, 109; meningioma, 50577NoneNoneHospitalXXHigh versus low grade gliomaT1 + CYP2D6None
  • Abbreviations: GBM, glioblastoma mutiforme; A, astrocytoma; AA, anaplastic astrocytoma; ODG, oligodendroglioma; OA, oligoastrocytoma.

  • * The number of subjects with genotypes.

  • Significant interaction of GSTT1 and P53 in patients with glioblastoma multiforme.

  • Significant interactions between GSTP1 I105V and A114V in glioma, I105V and CYP2E12 in glioma and acoustic neuroma.

  • § The authors used healthy controls published in the literature; GSTM1: 1473, GSTT1: 782, GSTP1 I105V: 1709, A114V:653.

  • Significant interaction.