Table 3.

Interaction between dietary intake of folate and vitamin B2 in colorectal adenoma risk

Dietary vitamin B2 intake (tertiles)Dietary folate intake (tertiles)
P trend
LowMediumHigh
Low
    N cases/controls97/11089/7864/49
    OR (95% CI)1 (reference)1.26 (0.82-1.94)1.34 (0.82-2.18)0.22
Medium
    N cases/controls67/78111/90110/67
    OR (95% CI)0.73 (0.46-1.15)1.04 (0.68-1.58)1.42 (0.92-2.19)0.01
High
    N cases/controls33/4876/69121/120
    OR (95% CI)0.56 (0.31-1.01)0.74 (0.45-2.22)0.69 (0.44-1.07)0.56
P trend0.310.010.02
P interaction0.64
  • NOTE: Intake of folate and vitamin B2 was adjusted for total energy intake, according to Willett and Stampfer (30), and for age and dietary calcium intake.