Table 2.

Association between dietary intake of folate and vitamin B2 and colorectal adenomas, stratified by MTHFR C677T genotype

MTHFR genotypeDietary intake (tertiles)*
P trend
LowMediumHigh
FolateAll
    N cases/controls197/236276/237295/236
    OR (95% CI)1 (reference)1.29 (0.98-1.69)1.32 (1.01-1.73)0.054
CC
    N cases/controls78/119123/104135/98
    OR (95% CI)1 (reference)1.67 (1.12-2.51)1.77 (1.18-2.65)0.01
CT
    N cases/controls88/84124/106126/112
    OR (95% CI)1.55 (1.00-2.39)1.59 (1.06-2.39)1.52 (1.02-2.27)0.88
TT
    N cases/controls25/3025/2327/25
    OR (95% CI)1.22 (0.65-2.30)1.41 (0.73-2.74)1.43 (0.75-2.73)0.69
P interaction, gene-nutrient0.34
Vitamin B2All
    N cases/controls250/237288/235230/237
    OR (95% CI)1 (reference)0.84 (0.64-1.10)0.51 (0.36-0.73)0.0002
CC
    N cases/controls102/114134/102100/105
    OR (95% CI)1 (reference)1.04 (0.69-1.55)0.57 (0.36-0.90)0.01
CT
    N cases/controls115/99115/105108/98
    OR (95% CI)1.21 (0.81-1.81)0.84 (0.56-1.27)0.68 (0.43-1.08)0.09
TT
    N cases/controls26/2234/2417/32
    OR (95% CI)1.22 (0.63-2.38)1.19 (0.64-2.22)0.32 (0.16-0.67)0.02
P interaction, gene-nutrient0.13
  • NOTE: Intake of folate and vitamin B2 was adjusted for total energy intake, according to Willett and Stampfer (30).

  • * Cut points for tertiles of daily dietary intake—women: vitamin B2, 1.27 mg/1.65 mg; folate, 160 μg/190 μg; men: vitamin B2, 1.51 mg/1.92 mg; folate, 191 μg/220 μg.

  • Adjusted for age.

  • Adjusted for age and dietary folate and calcium intake.