Table 5.

Unadjusted geometric mean (95% CI) urinary estrogen metabolites (measured at baseline by genotype)

Genotype
n
2-OHE/16-OHE Ratio
2-OHE1 (ng/mg creatinine)
16α-OHE1 (ng/mg creatinine)
Mean (95% CI)PMean (95% CI)PMean (95% CI)P
COMT
    Val/Val751.50 (1.32-1.71)20.0 (13.8-29.0)13.7 (11.9-15.7)
    Val/Met741.55 (1.36-1.76)0.18*21.5 (14.8-31.2)0.01*14.0 (12.2-16.0)0.36*
    Met/Met311.87 (1.53-2.29)0.1030.6 (21.1-44.4)0.00816.4 (13.2-20.2)0.22
    Val/Val + Val/Met1491.53 (1.39-1.67)0.0720.7 (16.3-26.3)0.00413.8 (12.6-15.2)0.16
CYP1A1*2A
    m1/m1881.60 (1.42-1.80)23.4 (20.3-27.0)14.6 (13.4-16.0)
    m1/m2671.63 (1.42-1.87)0.53*21.8 (18.5-25.7)0.35*13.5 (12.4-14.8)0.71*
    m2/m2241.40 (1.12-1.76)0.4718.7 (14.3-24.6)0.1614.5 (13.3-15.9)0.71
CYP1A1*2B
    AA1171.61 (1.45-1.78)22.3 (19.7-25.2)13.8 (12.4-15.4)
    AG541.56 (1.34-1.81)0.69*22.2 (18.5-26.6)0.91*14.4 (12.3-16.9)0.35*
    GG91.36 (0.94-1.98)0.4420.1 (13.1-30.9)0.7518.7 (12.6-27.7)0.24
CYP1A2*1F
    AA1001.79 (1.60-1.99)22.6 (19.8-25.8)13.0 (11.6-14.6)
    AC701.33 (1.17-1.51)0.003*22.4 (19.1-26.2)0.39*16.8 (14.7-19.3)0.004*
    CC101.61 (1.14-2.27)0.00816.5 (10.8-25.4)0.3710.3 (7.1-14.8)0.25
    AC + CC801.36 (1.21-1.53)0.001§21.6 (18.6-25.0)0.65§15.9 (13.9-18.0)0.03§
CYP1B1
    Val/Val791.49 (1.32-1.69)27.7 (19.5-26.4)15.4 (13.5-17.5)
    Val/Leu831.62 (1.44-1.84)0.41*21.3 (18.4-24.7)0.78*13.5 (11.8-15.3)0.31*
    Leu/Leu181.78 (1.38-2.30)0.1823.4 (17.1-31.9)0.3713.1 (10.0-17.2)0.15
CYP17
    TT661.55 (1.35-1.77)21.1 (17.9-24.9)14.1 (12.2-16.3)
    TC891.67 (1.48-1.87)0.89*23.3 (20.2-26.9)0.59*14.1 (12.5-16.0)0.33*
    CC251.39 (1.12-1.73)0.7020.8 (16.0-27.2)0.7915.0 (11.9-18.9)0.71
  • * P global test for comparison of means.

  • P for gene dosage effect.

  • P for testing a recessive genetic model.

  • § P for testing a dominant genetic model.