Table 4.

Geometric mean (95% CI) serum E2 before and after adjustment in mixed models for age, BMI, age at menarche, and parity by ethnicity and CYP1A2*1F genotype

CYP1A2*1FnE2 (pg/mL) unadjusted
E2 (pg/mL) adjusted
Mean (95% CI)PMean (95% CI)P
Asian
    AA38132.8 (119.3-147.8)132.6 (119.4-147.4)
    AC37123.1 (110.2-137.6)0.01*124.5 (11.6-139.0)0.13*
    CC387.1 (59.4-127.6)0.1088.5 (60.3-130.0)0.11
    AA + AC75127.9 (118.4-138.1)0.06128.6 (119.3-138.6)0.06
Caucasian
    AA47116.5 (106.0-128.1)117.1b (106.4-128.9)
    AC28144.4 (127.2-163.9)0.008*143.6 (126.3-163.4)0.009*
    CC387.7 (60.3-127.5)0.02585.3 (58.2-124.9)0.35
    AA + AC75137.7 (121.6-155.9)0.04136.7 (120.4-155.2)0.06
Mixed
    AA29133.9 (115.1-155.8)136.8 (117.2-159.7)
    AC14141.9 (115.5-174.3)0.79*140.9 (114.4-173.5)0.64*
    CC6125.1 (91.6-170.9)0.95117.7 (85.8-161.4)0.62
    AA + CC43137.5 (115.9-163.1)0.80134.5 (113.1-160.1)0.92
  • * P global test for comparison of means.

  • P for gene dosage effect.

  • P for testing a recessive genetic model.