Table 3.

Geometric mean (95% CI) serum E1 and E2 measured over a 2-year period, adjusted in a mixed model for ethnicity, age, BMI, age at menarche, and parity by genotype

GenotypenE1 (pg/mL)
E2 (pg/mL)
Mean (95% CI)PMean (95% CI)P
COMT
    Val/Val8480.1 (73.6-87.3)123.9 (114.0-134.7)
    Val/Met8388.0 (80.9-95.9)0.32*133.2 (122.6-144.7)0.49*
    Met/Met3184.3 (72.7-97.8)0.34128.4 (111.1-148.4)0.47
CYP1A1*2A
    m1/m110081.7 (75.3-88.5)124.7 (115.3-134.9)
    m1/m27185.4 (77.6-93.8)0.62*131.4 (119.9-144.1)0.66*
    m2/m22688.6 (76.1-103.2)0.33132.0 (113.8-153.1)0.41
CYP1A1*2B
    AA13081.0 (75.6-86.8)125.1 (116.9-133.8)
    AG5889.6 (81.0-99.2)0.27*134.9 (122.2-149.0)0.47*
    GG1088.0 (69.0-112.3)0.15130.6 (102.8-165.9)0.30
CYP1A2*1F
    AA11082.6 (76.8-88.9)128.3 (119.6-137.5)
    AC7688.6 (81.1-96.9)0.14*135.4 (124.3-147.5)0.01*
    CC1270.7 (56.9-87.8)0.9595.2 (77.3-117.2)0.31
    AA + AC18684.0 (79.5-88.7)0.16129.2 (122.6-136.2)0.01
CYP1B1
    Val/Val9181.2 (74.4-88.2)133.5 (123.1-144.8)
    Val/Leu8685.5 (78.7-92.8)0.53*124.4 (114.9-134.7)0.42*
    Leu/Leu2189.4 (75.3-106.3)0.26122.4 (103.5-144.8)0.22
CYP17
    TT7087.2 (79.7-95.5)128.3 (117.5-140.2)
    TC9684.0 (77.6-91.0)0.31*132.2 (122.3-142.8)0.33*
    CC3276.5 (66.7-87.9)0.14117.4 (102.6-134.3)0.46
  • * P global test for comparison of means.

  • P for gene dosage effect.

  • P for testing a recessive genetic model.