Table 2.

Unadjusted geometric mean (95% CI) serum E1 and E2 measured over a 2-year period by genotype

GenotypenE1 (pg/mL)
E2 (pg/mL)
Mean (95% CI)PMean (95% CI)P
COMT
    Val/Val8480.4 (74-87.3)123.7 (114.1-134.1)
    Val/Met8386.8 (79.9-94.3)0.42*131.3 (121.1-142.2)0.59*
    Met/Met3181.6 (71.3-93.5)0.56126.3 (110.7-144.1)0.57
CYP1A1*2A
    m1/m110081.1 (75.2-87.5)124.7 (115.8-134.2)
    m1/m27184.5 (77.2-92.4)0.53*128.5 (117.8-140.3)0.74*
    m2/m22688.8 (76.5-103.1)0.26132.2 (114.3-153.0)0.43
CYP1A1*2B
    AA13080.6 (75.4-86.1)124.2 (116.5-132.5)
    AG5888.4 (80.1-97.6)0.26*133.4 (121.1-146.9)0.46*
    GG1089.3 (70.4-113.4)0.12131.6 (104.1-166.3)0.26
CYP1A2*1F
    AA11082.1 (76.4-88.1)126.4 (118.0-135.3)
    AC7686.9 (79.7-94.8)0.25*133.9 (123.3-145.4)0.02*
    CC1272.1 (58.0-89.7)0.9797.3 (79.0-119.8)0.45
    AA+AC18684.0 (67.5-104.5)0.18129.4 (122.7-136.4)0.01
CYP1B1
    Val/Val9180.3 (74.2-86.9)131.2 (121.5-141.7)
    Val/Leu8685.2 (78.5-92.4)0.45*125.4 (115.9-135.7)0.44*
    Leu/Leu2188.3 (75.0-104.10)0.21117.9 (100.8-137.9)0.21
CYP17
    TT7087.2 (79.7-95.5)128.3 (117.5-140.1)
    TC9681.9 (75.8-88.4)0.41*131.1 (121.7-141.2)0.18*
    CC3279.1 (69.3-90.3)0.19114.1 (100.3-129.8)0.25
  • * P global test for comparison of means.

  • P for gene dosage effect.

  • P for testing a recessive genetic model.