Demographic and hormone characteristics of 88 postmenopausal women stratified by history of hormone therapy use
Baseline characteristics | Never users (n = 45) | Former users | ||||||
---|---|---|---|---|---|---|---|---|
All former users (n = 43) | Used <5 y ago (n = 20) | Used ≥5 y ago (n = 19) | ||||||
n (%) | n (%) | n (%) | n (%) | |||||
Ethnicity | ||||||||
Non-Hispanic White | 36 (80.0) | 41 (95.3) | 18 (90.0) | 19 (100.0) | ||||
Other | 9 (20.0) | 2 (4.7) | 2 (10.0) | 0 (0) | ||||
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||||
Age (y) | 60.5 (7.4) | 60.6 (6.3) | 58.1 (5.1) | 62.5 (6.6) | ||||
Percent mammographic density (%) | 6.7 (6.1) | 5.8 (4.6) | 6.6 (4.6) | 4.7 (4.2) | ||||
Dense breast area (1,000 pixels) | 27.4 (24.1) | 22.9 (14.9) | 24.8 (13.2) | 19.5 (15.3) | ||||
Total breast area (1,000 pixels) | 427.9 (100.0) | 427.3 (76.5) | 415.4 (82.5) | 448.6 (71.2) | ||||
Percent fat mass (dual-energy X-ray absorptiometry; %) | 43.4 (2.7) | 43.7 (3.1) | 43.7 (3.5) | 43.7 (3.1) | ||||
Estrone (pg/mL) | 48.0 (12.4) | 48.4 (19.9) | 50.0 (20.8) | 48.5 (205) | ||||
Estradiol (pg/mL) | 18.9 (5.9) | 18.7 (7.9) | 18.6 (8.7) | 19.5 (7.9) | ||||
Free estradiol (pg/mL) | 0.51 (0.18) | 0.51 (0.25) | 0.52 (0.28) | 0.53 (0.23) | ||||
Testosterone (pg/mL) | 237.4 (89.3) | 230.7 (106.3) | 249.8 (132.3) | 226.7 (77.4) | ||||
Free testosterone (pg/mL) | 5.1 (2.0) | 5.0 (2.4) | 5.6 (3.2) | 4.8 (1.2) | ||||
Androstenedione (ng/mL) | 613.2 (225.1) | 583.4 (251.6) | 617.3 (310.7) | 582.9 (192.0) | ||||
DHEA (ng/mL) | 2.7 (1.3) | 2.7 (1.6) | 3.0 (2.0) | 2.5 (1.2) | ||||
DHEA sulfate (μg/mL) | 67.1 (41.7) | 80.9 (67.1) | 96.3 (89.7) | 68.3 (33.9) | ||||
SHBG (nmol/L) | 42.3 (29.3) | 38.2 (19.7) | 35.8 (14.1) | 39.4 (21.3) | ||||
Follicle-stimulating hormone (mIU/L) | 68.0 (24.3) | 63.8 (19.9) | 67.7 (23.1) | 59.5 (17.6) | ||||
IGF-I (ng/mL) | 106.6 (31.5) | 111.7 (28.6) | 111.5 (32.1) | 110.9 (27.0) | ||||
IGFBP-3 (μg/mL) | 3.9 (1.0) | 4.1 (1.0) | 4.2 (0.9) | 3.8 (0.9) | ||||
IGF-I/IGFBP-3 ratio | 28.8 (12.1) | 28.5 (8.7) | 26.9 (5.3) | 30.3 (10.8) | ||||
Total cholesterol (mg/dL)* | 228.0 (38.2) | 239.6 (49.8) | 246.5 (65.1) | 237.6 (28.6) | ||||
LDL (mg/dL)† | 147.5 (35.6) | 160.2 (52.3) | 170.4 (69.1) | 155.3 (26.8) | ||||
HDL (mg/dL)† | 55.2 (12.9) | 52.5 (14.1) | 49.9 (13.8) | 54.6 (14.6) | ||||
LDL/HDL ratio† | 2.8 (1.0) | 3.4 (2.1) | 3.6 (2.9) | 3.1 (1.0) | ||||
Total cholesterol/HDL ratio† | 4.4 (1.3) | 5.0 (2.3) | 5.5 (3.1) | 4.6 (1.2) |