Table 1.

Association between N372H of BRCA2 and risk of breast cancer in the Nurses' Health Study Cohort

Case (%)Control (%)RR (95% CI)*
g30763310g789 (61)1,029 (61)1.00 (Reference)
g30763310a442 (34)591 (35)0.98 (0.83-1.15)
a30763310a59 (4.6)58 (3.5)1.31 (0.86-2.01)
N372N695 (54)884 (53)1.00 (Reference)
N372H501 (39)647 (39)0.99 (0.84-1.17)
H372H89 (6.9)129 (7.8)0.88 (0.65-1.19)
N372N/N372H1,196 (93)1,532 (92)1.00 (Reference)
H373H89 (6.9)129 (7.8)0.88 (0.65-1.19)
  • Abbreviation: RR, relative risk.

  • * Conditional logistic regression controlled for age of menopause, age at menarche, age at first birth, parity, postmenopausal hormone use, history of benign breast disease, and family history of breast cancer.