Table 1.

Risk of colon cancer associated with mEH genotypes

mEH genotypeMain effects*Usual number of cigarettes smoked per day*
Total mutagen index*,
None≤20>200-451452-831≥832
Y113H
    Y/Y1.0 (ref.)1.0 (ref.)1.2 (0.96-1.5)1.6 (1.2-2.1)1.0 (ref.)1.2 (0.9-1.5)1.1 (0.9-1.4)
789/991330/473305/380154/138223/315284/334282/342
    Y/H1.0 (0.9-1.2)1.0 (0.8-1.3)1.3 (1.0-1.6)1.5 (1.1-2.1)1.0 (0.8-1.3)1.2 (0.9-1.6)1.2 (0.9-1.5)
655/795272/376269/314114/105193/265223/260239/270
    H/H1.1 (0.8-1.4)1.1 (0.7-1.6)1.3 (0.90-1.9)1.5 (0.9-2.7)1.2 (0.8-1.8)1.0 (0.6-1.5)1.4 (0.9-2.1)
149/17455/7466/7528/2548/5844/6357/53
H139R
    H/H1.0 (ref.)1.0 (ref.)1.3 (1.1-1.5)1.5 (1.2-1.9)1.0 (ref.)1.2 (0.9-1.4)1.2 (0.9-1.4)
1,051/1,267436/610425/481190/176304/415371/433376/419
    H/R1.0 (0.8-1.1)1.0 (0.8-1.2)1.1 (0.9-1.4)1.6 (1.2-2.3)1.0 (0.8-1.3)1.1 (0.8-1.4)1.0 (0.8-1.4)
479/605194/276190/24895/81146/192154/191179/222
    R/R0.8 (0.6-1.2)1.0 (0.6-1.7)0.9 (0.5-1.5)1.4 (0.6-3.2)0.6 (0.3-1.2)1.0 (0.6-1.8)1.2 (0.7-2.2)
63/8827/3725/4011/114/3126/3323/24
Imputed phenotypes
    Rapid1.0 (0.8-1.2)1.0 (0.8-1.4)1.1 (0.8-1.5)1.7 (1.1-2.6)1.1 (0.7-1.5)1.3 (0.9-1.7)1.1 (0.8-1.5)
282/351109/151113/14860/5281/107103/11698/128
    Normal1.0 (ref.)1.0 (ref.)1.2 (0.9-1.5)1.6 (1.2-2.2)1.0 (ref.)1.2 (0.9-1.5)1.2 (0.9-1.5)
694/882306/441261/329127/112197/288236/290261/304
    Slow1.1 (0.9-1.2)1.0 (0.8-1.3)1.4 (1.1-1.7)1.4 (1.0-2.0)1.1 (0.8-1.4)1.3 (0.97-1.7)1.2 (0.9-1.6)
468/553187/257200/21781/79138/185168/188162/180
    Very slow1.1 (0.8-1.4)1.1 (0.7-1.6)1.3 (0.9-1.9)1.5 (0.9-2.7)1.2 (0.8-1.8)1.0 (0.7-1.6)1.4 (0.9-2.2)
149/17455/7466/7528/2548/5844/6357/53
Combined genotypes
    113YY/139HH1.0 (ref.)
507/640
    113YY/139HR1.0 (0.8-1.2)
247/310
    113YH/139HH1.1 (0.9-1.3)
444/513
    113YH/139HR1.0 (0.8-1.2)
187/242
    113HH/139HH or 139HR1.1 (0.8-1.4)
145/167
    Any Y113H/139RR0.9 (0.6-1.2)
63/88
  • NOTE: All estimates are multivariate adjusted for age, sex, body mass index (kg/m2), vigorous physical activity index, regular use of aspirin or nonsteroidal anti-inflammatory drugs, and usual number of cigarettes smoked per day where appropriate.

  • * Reported as OR (95% confidence interval), number of cases/number of controls.

  • Total mutagen index is calculated as the frequency of cooked red meat, poultry, and fish consumption plus the use of drippings multiplied by usual doneness of meat (1, rare; 2, medium-rare; 3, medium-well; 4, well done) and the microwave factor (1, never used; 0.75, sometimes used; 0.5, often used; 0.25, always used; ref. 20).

  • Imputed phenotype, as classified by Smith and Harrison (19): rapid, 113YY/139HR or 113YY/139RR; normal, 113YY/139HH or 113YH/139HR; slow, 113YH/139HH or 113YH/139RR; and very slow, 113HH/139HH.