Table 2.

Colorectal cancer ORs (95% CIs) for the IGFBP3 G2133C variant

GenotypeModel 1*
Model 2
nOR (95% CI)nOR (95% CI)
GG235/5851.00205/5371.00
GC355/8051.35 (1.09-1.69)302/7391.27 (1.01-1.60)
CC229/6051.25 (0.98-1.61)193/5261.22 (0.93-1.60)
P = 0.088P = 0.161
Any C1.32 (1.07-1.62)1.26 (1.00-1.57)
P = 0.008§P = 0.045
  • * Adjusted for age at blood draw, sex, and race/ethnicity by unconditional logistic regression.

  • Further adjusted for pack-years of cigarette smoking, body mass index, hours per week in vigorous activity, and fiber and ethanol intakes. Numbers of subjects differ due to missing covariates.

  • P for a gene-dosage effect variable assigned a value of 1, 2, or 3 according to the number of C alleles (zero, one, and two C alleles, respectively).

  • § P for dominant genetic effect.