Table 1.

Geometric means (95% CIs) for plasma IGFBP-3 and IGF-I/IGFBP-3 by IGFBP3 variant genotypes

GenotypenPlasma, IGFBP-3 (ng/mL)Molar ratio, IGF-I/IGFBP-3
G2133C
    GG2452,805 (2,682-2,994)0.208 (0.198-0.218)
    GC3502,701 (2,607-2,799)0.226 (0.218-0.235)
    CC2922,395 (2,299-2,495)0.237 (0.237-0.247)
    P<0.0001*0.0002
A202C
    AA2712,794 (2,680-2,912)0.207 (0.198-0.217)
    AC3752,672 (2,584-2,765)0.229 (0.211-0.238)
    CC2302,372 (2,268-2,482)0.235 (0.224-0.246)
    P<0.00010.0002
  • NOTE: Adjusted for age at blood draw, sex, and race/ethnicity by covariance analysis.

  • * P for a gene-dosage effect variable assigned a value of 1, 2, or 3 according to the number of variant alleles (zero, one, and two alleles, respectively).