Table 2.

Association of plasma sex steroid hormones and SHBG concentrations with prostate cancer among 448 matched pairs nested in the Health Professionals Follow-up Study, 1993-1998

Quartile*
Ptrend
1234
Testosterone
    No. cases/controls121/11396/115138/11293/108
    OR (95% CI)1.000.78 (0.54-1.13)1.18 (0.82-1.69)0.81 (0.56-1.18)0.72
    OR§ (95% CI)1.000.77 (0.52-1.14)1.17 (0.77-1.79)0.78 (0.48-1.28)0.73
Free testosterone
    No. cases/controls113/112107/112107/111121/113
    OR (95% CI)1.000.95 (0.66-1.36)0.95 (0.65-1.40)1.07 (0.74-1.54)0.74
Dihydrotestosterone
    No. cases/controls126/114100/112115/115107/107
    OR (95% CI)1.000.79 (0.54-1.17)0.89 (0.61-1.29)0.88 (0.59-1.33)0.70
    OR§ (95% CI)1.000.78 (0.52-1.16)0.88 (0.58-1.34)0.87 (0.55-1.39)0.73
Androstanediol glucuronide
    No. cases/controls104/115117/109115/113112/111
    OR (95% CI)1.001.18 (0.82-1.71)1.12 (0.77-1.64)1.11 (0.76-1.63)0.64
Estradiol
    No. cases/controls116/112117/113108/113107/110
    OR (95% CI)1.000.99 (0.68-1.44)0.91 (0.61-1.35)0.92 (0.61-1.39)0.62
    OR§ (95% CI)1.000.98 (0.67-1.43)0.91 (0.61-1.35)0.92 (0.61-1.39)0.62
SHBG
    No. cases/controls113/113121/115105/112109/108
    OR (95% CI)1.001.05 (0.72-1.52)0.93 (0.63-1.38)1.01 (0.69-1.47)0.88
  • * The case-control pairs were assayed in two analytic batches, cases diagnosed after the date of blood draw through 1/1996, and their matched controls and cases diagnosed from 2/1996 through 1/1998 and their matched controls. Quartile cut points for batch 1 were testosterone 4.18, 5.27, 6.69 ng/mL; free testosterone 21.7, 26.5, 32.2 pg/mL; dihydrotestosterone 215, 357, 510 pg/mL; androstanediol glucuronide 3.57, 4.97, 6.97 ng/mL; estradiol 18.9, 24.0, 27.9 pg/mL; and SHBG 91.8, 121, 154 nmol/L. Quartile cut points for batch 2 were testosterone 3.25, 4.32, 5.43 ng/mL; free testosterone 22.0, 26.7, 32.8 pg/mL; dihydrotestosterone 307, 426, 595 pg/mL; androstanediol glucuronide 2.71, 3.76, 5.01 ng/mL; estradiol 28.6, 32.7, 37.7 pg/mL; and SHBG 53.7, 72.4, 91.5 nmol/L.

  • Matched on age, time of day and year of blood draw, and PSA test before blood draw.

  • Reference group.

  • § Adjusted for SHBG.