Table 3.

ORs of stage and grade of prostate cancer according to quartiles of mutually adjusted plasma sex steroid hormone concentrations or the molar ratio of estradiol to testosterone, 448 matched pairs nested in the Health Professionals Follow-up Study, 1993-1998

Quartile
Ptrend
1234
Total prostate cancer (448 cases/448 controls)
    Testosterone1.00*0.771.180.79 (0.48-1.31)0.79
    Androstanediol glucuronide1.00*1.191.161.19 (0.80-1.77)0.57
    Estradiol1.00*0.980.900.90 (0.59-1.39)0.58
    SHBG1.00*1.090.951.09 (0.66-1.82)0.97
    Estradiol to testosterone1.00*1.170.861.25 (0.79-1.99)0.64
Regionally invasive or metastatic (40 cases/40 controls)
    Testosterone1.00*0.440.890.48 (0.06-3.69)0.28
    Androstanediol glucuronide1.00*13.864.386.38 (0.89-45.9)0.13
    Estradiol1.00*3.101.741.11 (0.17-7.23)0.31
    SHBG1.00*3.083.134.85 (0.33-71.9)0.17
    Estradiol to testosterone1.00*3.343.334.57 (0.86-24.2)0.11
Organ confined or minimal extraprostatic extension (339 cases/339 controls)
    Testosterone1.00*0.871.211.00 (0.56-1.89)0.73
    Androstanediol glucuronide1.00*1.061.031.10 (0.70-1.72)0.85
    Estradiol1.00*0.860.750.87 (0.52-1.46)0.51
    SHBG1.00*1.120.931.08 (0.61-1.94)0.94
    Estradiol to testosterone1.00*1.090.641.00 (0.58-1.72)0.54
Gleason sum ≥ 7 (148 cases/148 controls)
    Testosterone1.00*0.600.500.26 (0.10-0.66)0.01
    Androstanediol glucuronide1.00*1.931.810.82 (0.38-1.75)0.87
    Estradiol1.00*1.200.971.15 (0.50-2.65)0.65
    SHBG1.00*1.822.902.72 (1.02-7.24)0.05
    Estradiol to testosterone1.00*2.060.903.02 (1.29-7.04)0.03
Gleason sum < 7 (229 cases/229 controls)
    Testosterone1.00*0.882.041.91 (0.89-4.07)0.02
    Androstanediol glucuronide1.00*1.201.201.49 (0.84-2.65)0.32
    Estradiol1.00*0.580.520.60 (0.31-1.13)0.20
    SHBG1.00*1.090.590.71 (0.34-1.50)0.13
    Estradiol to testosterone1.00*0.660.570.47 (0.23-0.96)0.04
  • NOTE: Matched on age, time of day and year of blood draw, and PSA test before blood draw. Mutually adjusted (except for estradiol to testosterone ratio) and estimated from conditional logistic regression models.

  • * Reference group.

  • 95% CI.