Table 4.

The distribution of SULT1A1 and SULT1E1 diplotypes and the respective breast cancer risks

CaseControlOR (95% CI)
SULT1A1*
GAC-GAC597 (61.0)598 (59.6)1.0 (reference)
GAC-AGT173 (17.7)184 (18.3)0.9 (0.74-1.21)
GAC-GAT189 (19.3)193 (19.2)1.0 (0.80-1.28)
GAT-AGT14 (1.4)18 (1.8)0.7 (0.33-1.39)
Others6 (0.61)11 (1.1)0.6 (0.23-1.78)
Total979 (100.0)1,004 (100.0)
SULT1E1
CTG-CTG234 (24.4)218 (22.2)1.0 (reference)
CTG-CTA176 (18.3)217 (22.1)0.8 (0.59-1.03)
CTG-CCA73 (7.6)52 (5.3)1.4 (0.90-2.05)
CTG-ATG224 (23.3)195 (19.8)1.1 (0.80-1.38)
CTA-CTA43 (4.5)37 (3.8)1.1 (0.64-1.72)
CTA-CCA15 (1.6)32 (3.3)0.5 (0.24-0.88)
CTA-ATG91 (9.5)111 (11.3)0.8 (0.57-1.13)
CCA-CCA5 (0.5)6 (0.6)0.9 (0.24-3.02)
CCA-ATG24 (2.5)23 (2.3)0.9 (0.49-1.66)
ATG-ATG50 (5.2)58 (5.9)0.8 (0.55-1.30)
Others25 (2.6)34 (3.5)0.7 (0.39-1.22)
Total960 (100.0)983 (100.0)
  • NOTE: Adjusted for age, family history of breast cancer, and lifetime estrogen exposure.

  • * Combination of SULT1A1 haplotypes reconstructed from SULT1A1 c.779G>A, *14A>G, and *85C>T.

  • Combination of SULT1E1 haplotypes reconstructed from SULT1E1 IVS1-447C>A, IVS4-1653T>C, and *959G>A.