Table 2.

The distribution of SULT1A1 and SULT1E1 genotypes and the respective breast cancer risks

Case n (%)Control n (%)OR (95% CI)
SULT1A1
c.779G>A
GG796 (80.7)830 (79.4)1.0 (reference)
GA190 (19.3)215 (20.6)0.9 (0.74-1.15)
AA0 (0)0 (0)
*14A>G
AA796 (80.7)822 (78.8)1.0 (reference)
AG190 (19.3)220 (21.1)0.9 (0.71-1.10)
GG1 (0.1)1 (0.1)
*85C>T
CC599 (61.0)606 (59.7)1.0 (reference)
CT365 (37.2)388 (38.2)1.0 (0.81-1.17)
TT18 (1.8)21 (2.1)0.8 (0.42-1.55)
SULT1E1
IVS1-447 C>A
CC559 (58.2)581 (58.9)1.0 (reference)
CA348 (36.2)344 (34.9)1.0 (0.85-1.26)
AA54 (5.6)61 (6.2)1.0 (0.64-1.42)
IVS4-1653 T>C
TT843 (85.4)890 (85.4)1.0 (reference)
TC135 (13.7)143 (13.7)1.0 (0.77-1.28)
CC9 (0.9)9 (0.9)1.0 (0.37-2.71)
*959G>A
GG536 (54.3)511 (49.5)1.0 (reference)
GA383 (38.8)434 (42.0)0.9 (0.71-1.03)
AA69 (7.0)88 (8.5)0.7 (0.53-1.05)*
GA/AA452 (45.7)522 (50.5)0.8 (0.70-1.00)
  • NOTE: OR adjusted for age, family history of breast cancer, and lifetime estrogen exposure.

  • * Ptrend = 0.035.