Table 4.

Patient characteristics and atypia by fluid-yielding duct status

Patient characteristicsAtypia from all non–fluid-yielding ducts (n = 12)Atypia from any fluid-yielding duct (n = 5)Two-sided P value*
Median age (years)39380.96
BRCA mutation9 (75%)2 (40.0%)0.28
Prior breast cancer4 (33.3%)0 (0%)0.26
Prior ovarian cancer3 (25%)0 (0%)0.51
Prior breast or ovarian cancer7 (58.3%)0 (0%)0.044
Prior chemotherapy7 (58.3%)0 (0%)0.044
Prior breast radiation3 (25%)0 (0%)0.51
Prior or current selective estrogen response modulator use2 (16.7%)0 (0%)1.0
Prior or current oral contraceptive pill use10 (83.3%)3 (60%)0.54
Prior or current hormone replacement therapy use5 (41.7%)1 (20%)0.60
Parous8 (66.7%)3 (60%)1.0
Breastfed10 (83.3%)2 (40%)0.12
Premenopausal4 (33.3%)4 (80%)0.13
Bilateral salpingo-oophorectomy before ductal lavage8 (66.7%)1 (20%)0.13
Prior breast biopsy7 (58.3%)1 (20%)0.29
  • * Two-sided P values from Fisher's exact test for categorical variables and Mann-Whitney U test for continuous variables.

  • Of the nine BRCA mutation carriers with atypia from non–fluid-yielding ducts, seven had BRCA1 mutations, and two had BRCA2 mutations; of the two BRCA mutation carriers with atypia from fluid yielding ducts, one had a BRCA1 mutation, and one had a BRCA2 mutation.