Table 1.

Patient characteristics and ductal lavage success

Patient characteristicsDuctal lavage attempted (n = 75)Ductal lavage successful* (n = 60)Ductal lavage unsuccessful (n = 15)Two-sided P value,§
Median age (years)4341530.0003
BRCA143 (57.3%)34 (56.7%)9 (60%)1.0
BRCA213 (17.3%)11 (18.3%)2 (13.3%)1.0
Prior breast cancer19 (25.3%)14 (23.3%)5 (33.3%)0.51
Prior ovarian cancer8 (10.7%)6 (10%)2 (13.3%)0.66
Prior chemotherapy24 (32%)19 (31.7%)5 (33.3%)1.0
Prior breast radiation12 (16%)9 (15%)3 (20%)0.70
Prior or current selective estrogen response modulator use15 (20%)10 (16.7%)5 (33.3%)0.16
Prior or current oral contraceptive pill use62 (82.7%)50 (83.3%)12 (80%)0.72
Prior or current hormone replacement therapy use20 (26.7%)15 (25%)5 (33.3%)0.53
Parous53 (70.7%)43 (71.7%)10 (66.7%)0.76
Breastfed41 (54.7%)34 (56.7%)7 (46.7%)0.57
Premenopausal31 (41.3%)31 (51.7%)3 (20%)0.041
Bilateral salpingo-oophorectomy before ductal lavage37 (49.3)29 (48.3%)8 (53.3%)0.78
Prior breast biopsy40 (53.3%)32 (53.3%)8 (53.3%)1.0
Ever fluid-yielding on suction aspiration30 (40%)29 (48.3%)1 (6.7%)0.0029
  • * Ductal lavage considered successful if a catheter could be inserted into one or more ducts, and saline instilled.

  • Ductal lavage considered unsuccessful if a catheter could not be inserted into any duct, or saline could not be instilled.

  • Two-sided P values from Fisher's exact test for categorical variables and Mann-Whitney U test for continuous variables.

  • § For comparison of successful versus unsuccessfully lavaged patients.