Table 2.

IGF-1 and IGFBP-3 genotype and colorectal cancer risk

ControlsAll casesMale casesFemale casesAll casesMale casesFemale cases
n (%)n (%)n (%)n (%)OR (95% CI)OR (95% CI)OR (95% CI)
IGF-1 genotype*,
    19/19217 (43.1)296 (37.9)138 (41.2)158 (35.3)1.01.01.0
    Other286 (56.9)486 (62.1)197 (58.8)289 (64.7)1.3 (1.0-1.6)1.0 (0.7-1.4)1.5 (1.1-2.0)
    Pinteraction0.08
IGF-1 genotype*,
    19/19217 (45.3)296 (41.0)138 (44.8)158 (38.2)1.01.01.0
    18/183 (0.6)5 (0.7)2 (0.6)3 (0.7)1.3 (0.3-5.7)0.7 (0.1-8.3)1.6 (0.3-10.0)
    18/1945 (9.4)46 (6.4)15 (4.9)31 (7.5)0.8 (0.5-1.2)0.5 (0.2-1.0)1.0 (0.6-1.7)
    18/207 (1.5)22 (3.0)8 (2.6)14 (3.4)2.4 (1.0-5.7)3.1 (0.4-25.9)2.2 (0.8-6.0)
    18/216 (1.3)10 (1.4)3 (1.0)7 (1.7)1.4 (0.5-3.9)1.3 (0.1-12.4)1.4 (0.4-4.7)
    19/20112 (23.4)198 (27.4)79 (25.6)119 (28.7)1.4 (1.0-1.9)1.1 (0.6-1.8)1.6 (1.1-2.4)
    19/2144 (9.2)81 (11.2)38 (12.3)43 (10.4)1.3 (0.9-2.0)1.1 (0.6-2.1)1.5 (0.9-2.5)
    20/2027 (5.6)30 (4.2)13 (4.2)17 (4.1)0.8 (0.4-1.3)0.5 (0.2-1.1)1.1 (0.5-2.3)
    20/2114 (2.9)28 (3.9)10 (3.2)18 (4.3)1.7 (0.8-3.3)2.6 (0.5-12.3)1.5 (0.7-3.3)
    21/214 (0.8)6 (0.8)2 (0.6)4 (1.0)1.0 (0.3-3.8)0.5 (0.1-3.6)1.7 (0.3-9.4)
    Pinteraction0.70
IGFBP-3 genotype§
    CC182 (36.2)248 (31.7)102 (30.4)146 (32.7)1.01.01.0
    GC226 (44.9)361 (46.2)157 (46.9)204 (45.6)1.2 (0.9-1.5)1.0 (0.6-1.6)1.2 (0.9-1.7)
    GG95 (18.9)173 (22.1)76 (22.7)97 (21.7)1.3 (1.0-1.8)1.5 (0.8-2.6)1.3 (0.9-1.9)
    Ptrend0.060.230.18
    Pinteraction0.62
  • * Adjusted for age and postmenopausal hormone use (women).

  • n's and %'s between collapsed (19/19 and other) and detailed (19/19, 18/18, etc.) parameterizations of IGF-1 genotype will differ, because less common alleles were included in collapsed parameterization, but excluded in detailed.

  • P < 0.05.

  • § Adjusted for age.