Table 2.

Relations of IGFs and breast density

Premenopausal women (n = 783)
Postmenopausal women (n = 791)
nIGF-I (ng/mL)IGFBP-3 (ng/mL)IGF-I/IGFBP-3 molar rationIGF-I (ng/mL)IGFBP-3(ng/mL)IGF-I/IGFBP-3 molar ratio
Breast density (%)Mean values of IGFs*Mean values of IGFs*
    <5.048212.95,0610.160196185.05,0230.135
    5.0-24.9169225.74,8890.169369193.04,9620.141
    25.0-44.9217221.54,8470.167158197.84,8030.144
    45.0-64.9193223.94,7320.16953188.55,0090.136
    ≥65.0156229.94,6940.17515218.24,5130.160
Type of adjustmentrs (P)rs (P)
    Crude0.046 (0.194)−0.152 (<0.0001)0.162 (<0.0001)0.123 (0.0005)0.030 (0.399)0.132 (0.0002)
    IGF-I or IGFBP-3 (if applicable)0.158 (<0.0001)−0.213 (<0.0001)0.134 (0.0002)−0.061 (0.086)
    Confounding factors*0.083 (0.021)−0.124 (0.0005)0.069 (0.056)0.032 (0.365)−0.013 (0.724)0.029 (0.410)
  • * Means and correlations are adjusted for age (years), BMI (kg/m2), IGF-I (ng/mL), or IGFBP-3 (ng/mL) if applicable.

  • Spearman correlation between continuous variables. Adjusted correlations are partial Spearman coefficients.