Table 4.

ORs and 95% CIs for the combined MTR and MTRR genotypes associated with SCCHN risk

MTR A2756G/MTRR G66A combinedNo. risk allelesCases (n = 721), n (%)Controls (n = 1,234), n (%)Crude OR (95% CI)Adjusted OR (95% CI)*
MTR AA/MTRR AA076 (10.5)200 (16.2)1.00 (reference)1.00 (reference)
MTR AA/MTRR GA or MTR AG/MTRR AA1281 (39.0)486 (39.4)1.52 (1.12-2.06)1.47 (1.08-1.99)
MTR AA/MTRR GG or MTR AG/MTRR GA or MTR GG/MTRR AA2276 (38.3)420 (34.0)1.73 (1.28-2.34)1.67 (1.23-2.27)
MTR AG/MTRR GG or MTR GG/MTRR GA or MTR GG/MTRR GG3 or 488 (12.2)128 (10.4)1.81 (1.24-2.64)1.74 (1.18-2.54)
P0.003
Ptrend0.0010.002
  • NOTE: The combined MTR AA and MTRR AA genotype had zero risk allele of either gene; the MTR AA and MTRR GA or MTR AG/MTRR AA genotype had only one risk allele; the MTR AA and MTRR GG or MTR AG and MTRR GA or MTR GG and MTRR AA had two risk alleles; and MTR AG and MTRR GG or MTR GG and MTRR GA or MTR GG/MTRR GG had three or four risk alleles.

  • * ORs were adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.

  • χ2 test for the distribution of the combined genotypes between the cases and controls.

  • Obtained in a logistic regression model with adjustments for age, sex, smoking status, and alcohol use. However, there was no evidence for an interaction with other variables listed in Table 3.