Table 3.

Associations and stratification analysis between the MTR and MTRR polymorphisms and SCCHN risk

Variablesn (cases/controls)MTR A2756G
MTRR G66A
Percentage (cases/controls)
Adjusted OR (95% CI)*
Percentage (cases/controls)
Adjusted OR (95% CI)*
AAAGGGAGGGGGGAAAGAAA
Total721/1,23465.4/71.032.2/26.52.4/2.532.0/29.952.2/47.715.8/22.4
Age (y)
    ≤55332/54066.3/72.831.3/25.42.4/1.81.43 (1.05-1.96)1.72 (0.65-4.55)30.1/29.552.7/47.017.2/23.51.11 (0.80-1.54)0.70 (0.47-1.06)
    >55389/69464.8/69.632.9/27.42.3/3.01.29 (0.98-1.71)0.78 (0.35-1.75)33.7/30.251.7/48.314.6/21.50.98 (0.73-1.30)0.61 (0.41-0.90)
    Pinteraction0.4840.571
Sex
    Female181/32062.4/72.235.4/23.72.2/4.11.70 (1.12-2.58)0.64 (0.20-2.06)33.1/30.049.2/49.717.7/20.30.90 (0.59-1.39)0.75 (0.43-1.31)
    Male540/91466.5/70.531.1/27.52.4/2.01.24 (0.98-1.57)1.38 (0.66-2.89)31.7/29.953.1/47.015.2/23.11.06 (0.83-1.36)0.62 (0.45-0.86)
    Pinteraction0.7250.534
Smoking status
    Never188/37168.6/74.429.3/24.32.1/1.31.33 (0.90-1.99)1.72 (0.45-6.57)33.5/29.950.0/43.916.5/26.21.02 (0.69-1.53)0.57 (0.34-0.96)
    Former282/54966.3/69.631.2/27.02.5/3.41.22 (0.89-1.67)0.75 (0.31-1.82)32.6/28.854.6/47.312.8/23.91.02 (0.74-1.42)0.47 (0.30-0.74)
    Current251/31462.1/69.435.5/28.32.4/2.31.34 (0.92-1.93)1.16 (0.38-3.56)30.3/31.851.0/52.918.7/15.31.01 (0.69-1.49)1.24 (0.74-2.07)
    Pinteraction<0.0010.012
Drinking status
    Never157/37366.9/69.731.8/28.21.3/2.11.20 (0.80-1.81)0.57 (0.12-2.76)33.1/27.649.1/45.617.8/26.80.88 (0.57-1.36)0.54 (0.32-0.93)
    Former195/32263.6/71.433.3/24.53.1/4.11.53 (1.03-2.27)0.86 (0.32-2.36)31.8/28.652.8/52.815.4/18.60.92 (0.61-1.38)0.75 (0.43-1.29)
    Current369/53965.9/71.631.7/26.52.4/1.91.29 (0.96-1.73)1.52 (0.60-3.84)31.7/32.353.1/46.215.2/21.51.16 (0.86-1.58)0.71 (0.48-1.06)
    Pinteraction0.2590.470
Tumor site
    Oral cavity222 (30.8)60.836.03.21.58 (1.16-2.16)1.27 (0.54-2.97)35.146.918.00.83 (0.60-1.15)0.72 (0.48-1.10)
    Pharynx363 (50.3)67.230.02.81.24 (0.95-1.61)1.38 (0.66-2.91)31.155.913.01.15 (0.88-1.50)0.55 (0.38-0.81)
    Larynx136 (18.9)68.431.60.01.17 (0.79-1.73)-29.450.719.91.06 (0.70-1.61)1.00 (0.59-1.68)
  • * ORs were adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.

  • This significance disappeared when comparison was made between groups of never versus ever users (P = 0.758 for MTR and P = 0.743 for MTRR).

  • Included both oropharyngeal, and hypopharyngeal cancer cases.