Table 2.

MTR A2756G and MTRR G66A genotype and allele frequencies among the cases and controls and logistic regression analysis for associations with SCCHN risk

GenotypesCases, n (%)Controls*, n (%)PCrude OR (95% CI)Adjusted OR (95% CI)
Total no. of subjects7211,234
Total no. of alleles1,4422,468
MTR A2756G
    AA472 (65.4)876 (71.0)0.0281.00 (reference)1.00 (reference)
    AG232 (32.2)327 (26.5)1.32 (1.08-1.61)1.31 (1.07-1.60)
    GG17 (2.4)31 (2.5)1.02 (0.56-1.86)1.00 (0.55-1.84)
    AG/GG249 (34.5)358 (29.0)0.0111.29 (1.06-1.57)1.28 (1.05-1.56)
        G allele0.1840.1580.155
MTRR G66A
    GG231 (32.0)369 (29.9)0.0021.00 (reference)1.00 (reference)
    GA376 (52.2)589 (47.7)1.02 (0.83-1.26)1.02 (0.82-1.26)
    AA114 (15.8)276 (22.4)0.66 (0.50-0.87)0.68 (0.52-0.90)
    GA/AA490 (68.0)865 (70.1)0.3230.90 (0.74-1.10)0.91 (0.75-1.11)
        A allele0.4180.4620.072
  • * The observed genotype frequency among the control subjects was in agreement with Hardy-Weinberg equilibrium (p2 + 2pq + q2 = 1) (χ2 = 0.00, P = 0.941 for MTR A2756G and χ2 = 2.22, P = 0.136 for MTRR G66A).

  • Two-sided χ2 test for either genotype distribution or allele frequency.

  • Adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.