Table 6.

Joint estimates of the effects of total area of dense tissue, lacunarity, and Wolfe grade on subsequent risk of breast cancer, Guernsey IV study, United Kingdom

Quantitative measures of mammographic features only
Wolfe qualitative classification only
Quantitative measures of mammographic features and Wolfe classification
HR* (95% CI)HR* (95% CI)HR* (95% CI)
Total area of dense tissue (cm2)
HR per 1 SD increase1.59 (1.29-1.94)1.30 (1.01-1.69)
HR per 1 SD increase0.61 (0.47-0.78)0.70 (0.53-0.92)
Wolfe grade
P12.06 (1.08-3.94)1.80 (0.93-3.48)
P23.50 (1.98-6.21)2.60 (1.37-4.92)
DY3.90 (1.76-8.62)2.31 (0.95-5.62)
Plinear trend<0.0010.005
  • * Hazard ratios (HR) and 95% confidence interval (CI) adjusted for the effect of age, age at leaving full time education, social class, job status, parity, height, BMI at G III, BMI change from GIII to GIV and the other variables in the column.