Table 2.

Separate effect of mammographic features on subsequent risk of breast cancer, Guernsey IV study, United Kingdom

Mammographic featureCategory*P
Wolfe's gradeN1P1P2DY
    D17215812<0.001
HR§ (95% CI)1.002.06 (1.08-3.94)3.50 (1.98-6.21)3.90 (1.76-8.62)
Percent breast density0.50-18.7-31.7-45.9-80.5
D133233300.001
HR§ (95% CI)1.002.71 (1.40-5.24)3.11 (1.59-6.12)3.49 (1.69-7.18)
HR§ per 1 SD increase1.40 (1.12, 1.75)0.003
Total area of dense tissue (cm2)0.39-18.8-30.2-45.4-169.9
D142934310.003
HR§ (95% CI)1.002.21 (1.16-4.22)2.68 (1.42-5.04)2.69 (1.40-5.16)
HR§ per 1 SD increase1.27 (1.07-1.51)0.05
Total area of lucent tissue (cm2)6.4-45.4-70.6-103.8-334.9
D332130240.179
HR§ (95% CI)1.000.56 (0.32-0.98)0.74 (0.42-1.29)0.56 (0.29-1.11)
HR§ per 1 SD increase0.76 (0.57-1.02)0.064
Total area of the breast (cm2)19.2-78.6-105.4-140.6-339.4
D282822300.874
HR§ (95% CI)1.000.96 (0.56-1.64)0.77 (0.43-1.40)1.03 (0.54-1.96)
HR§ per 1 SD increase0.98 (0.76-1.26)0.855
Breast volume (cm3)79.3-496.8-715.7-1,009.0-3,416.6
D332424270.310
HR§ (95% CI)1.000.67 (0.39-1.15)0.65 (0.36-1.15)0.73 (0.38-1.40)
HR§ per 1 SD increase0.98 (0.75-1.29)0.823
Fractal dimension2.68-2.85-2.90-2.96-3.24
D253727190.174
HR§ (95% CI)1.001.52 (0.91-2.54)1.02 (0.58-1.80)0.70 (0.36-1.34)
HR§ per 1 SD increase0.80 (0.64-1.00)0.046
Lacunarity4.16-4.88-4.99-5.10-5.51
D332821260.207
HR§ (95% CI)1.000.79 (0.47-1.31)0.60 (0.34-1.07)0.74 (0.41-1.32)
HR§ per 1 SD increase0.80 (0.65-1.00)0.046
Regional skewness−0.228-0.267-0.475-0.776-5.539
D272233290.562
HR§ (95% CI)1.000.85 (0.48-1.49)1.21 (0.72-2.03)1.05 (0.62-1.80)
HR§ per 1 SD increase1.02 (0.84-1.24)0.823
  • * Fourths of the distribution in the whole cohort, except for Wolfe grade.

  • P for linear trend.

  • Number of breast cancer cases (three excluded due to missing data on potential confounding variables).

  • § HRs (and 95% CIs) adjusted for age, age at leaving full time education, social class, job status, parity, height, BMI at GIII, and BMI change from GIII to GIV.