Serum sex hormone concentrations and other risk factors for ER+ breast cancer in the nested case-cohort study
| Factor | Age-adjusted | Adjusted* | ||||||
|---|---|---|---|---|---|---|---|---|
| Relative risk (95% CI) | P | Relative risk (95% CI) | P | |||||
| Weight (per 10 kg) | 1.2 (1.1-1.3) | 0.002 | 1.1 (0.9-1.4) | 0.26 | ||||
| Education (>16 y) | 1.5 (1.0-2.2) | 0.05 | 2.1 (1.1-4.2) | 0.03 | ||||
| Distal radius BMD† | 1.2(1.1-1.4) | 0.003 | 1.2 (0.9-1.5) | 0.20 | ||||
| Testosterone‡ | ||||||||
| Quintile 1 (reference) | 1.0 | 1.0 | ||||||
| Quintile 2 | 2.6 (1.2-5.4) | 0.01 | 2.4 (1.1-5.5) | 0.03 | ||||
| Quintile 3 | 2.1 (1.0-4.4) | 0.06 | 2.2 (0.9-5.0) | 0.07 | ||||
| Quintile 4 | 3.8 (1.9-7.8) | 4.001 | 4.0 (1.8-8.6) | <0.001 | ||||
| Quintile 5 | 5.1 (2.5-10.3) | <0.001 | 3.8 (1.7-8.4) | 0.001 | ||||
| Estradiol§ | ||||||||
| Quintile 1 (reference) | 1.0 | 1.0 | ||||||
| Quintile 2 | 0.8 (0.4-1.8) | 0.63 | 0.7 (0.3-1.7) | 0.44 | ||||
| Quintile 3 | 1.4 (0.8-2.5) | 0.30 | 1.2 (0.6-2.2) | 0.66 | ||||
| Quintile 4 | 1.8 (0.9-3.5) | 0.08 | 1.3 (0.6-2.8) | 0.45 | ||||
| Quintile 5 | 2.9 (1.6-5.1) | <0.001 | 1.8 (0.9-3.6) | 0.11 | ||||
Abbreviation: BMD, bone mineral density.
↵* Adjusted for weight, education, radius BMD, testosterone, and estradiol. Ptrend for estradiol = 0.06 and Ptrend for testosterone < 0.001.
↵† Per SD increase.
↵‡ Quintiles for testosterone (pmol/L): 1st, <381; 2nd, 381-553; 3rd, 554-727; 4th, 728-1074; 5th, >1,074.
↵§ Quintiles for estradiol (pmol/L): 1st, <14; 2nd, 14-17; 3rd, 18-24; 4th, 25-32; 5th, >32.