Table 3.

Relationship between dietary folate and risk of prostate cancer in strata of selected covariates. Italy, 1991-2002

Approximated quintile* of folate intake, OR (95% CI)
P for trend
1 (low)2345 (high)
Age
    <6510.72 (0.49-1.04)0.67 (0.46-0.93)0.71 (0.49-1.01)0.48 (0.33-0.70)0.0005
    ≥6510.94 (0.68-1.31)1.11 (0.79-1.55)0.97 (0.69-1.36)0.86 (0.61-1.22)0.54
Alcohol intake
    Tertile 110.85 (0.55-1.32)1.17 (0.74-1.85)0.82 (0.52-1.28)0.68 (0.43-1.08)0.13
    Tertile 210.92 (0.60-1.40)0.81 (0.53-1.21)0.88 (0.58-1.33)0.83 (0.55-1.28)0.42
    Tertile 310.75 (0.49-1.17)0.72 (0.47-1.09)0.78 (0.51-1.19)0.44 (0.27-0.70)0.0025
Vitamin B6
    Tertile 110.97 (0.67-1.41)1.04 (0.70-1.54)1.02 (0.66-1.58)0.92 (0.54-1.56)0.93
    Tertile 210.82 (0.53-1.26)0.85 (0.56-1.31)0.81 (0.52-1.25)0.61 (0.38-0.97)0.07
    Tertile 310.46 (0.25-0.85)0.52 (0.30-0.92)0.51 (0.29-0.88)0.42 (0.24-0.72)0.015
Methionine intake
    Tertile 111.18 (0.77-1.83)1.35 (0.87-2.11)1.11 (0.70-1.73)0.94 (0.60-1.46)0.76
    Tertile 210.75 (0.48-1.17)0.71 (0.46-1.11)0.83 (0.53-1.30)0.67 (0.42-1.08)0.22
    Tertile 310.64 (0.42-0.98)0.66 (0.44-1.00)0.65 (0.43-0.99)0.47 (0.30-0.72)0.002
  • * Folate, methionine, and vitamin B6 intake were energy adjusted using the residual method.

  • Estimates from unconditional logistic regression models adjusted for age, study center, education, body mass index, alcohol consumption, smoking habit, family history of prostate cancer, and nonalcohol energy intake. The reference category was the first (lowest) quintile of intake.