Table 2.

Biochemical data according to the combined presence of MTHFR 1298A>C and 677C>T genotypes

Group 1 (1298AA/677TT), N = 72Group 2 (1298AA/677CC), N = 19Group 3 (1298CC/677CC), N = 42P (group 1 vs group 2)P (group 1 vs group 3)P (group 2 vs group 3)
Plasma folate (nmol/L)10.73 (9.73-11.85)11.52 (9.31-14.25)12.62 (11.15-14.30)0.5130.0430.440
Vitamin B12 (pmol/L)437 (391-487)487 (369-642)433 (383-488)0.4500.9000.419
Vitamin B6 (nmol//L)30.53 (26.62-35.02)21.03 (16.05-27.52)28.59 (23.01-35.51)0.0160.6070.090
tHcy (μmol/L)19.57 (17.18-22.28)15.79 (13.34-18.70)14.41 (12.83-16.18)0.0450.0010.358
Genomic DNA methylation (ng mCyt/μg DNA)3.11 (2.16-4.49)7.29 (4.64-11.44)7.14 (5.26-9.67)0.0040.0010.936
  • NOTE: Plasma folate, vitamin B12, vitamin B6, tHcy, and genomic DNA methylation are presented as geometric means (antilogarithms of the transformed means) and 95% confidence intervals are reported in parentheses with two-tailed P values. Statistical difference was evaluated by Student's t test except when differently indicated. Statistical difference was evaluated by χ2 test.