Table 3.

Risk estimates for non-Hodgkin's lymphoma associated with cigarette smoking in the pooled study population

Smoking exposureControls/casesOR (95% CI)*P for linear trend
Nonsmoker3,914/2,8291.00 (Reference)
Ever smoker4,978/3,7651.07 (1.00-1.15)
    Current2,100/1,4951.10 (1.00-1.20)
    Former2,874/2,2621.06 (0.98-1.15)
Years since quit
    1-10876/6101.09 (0.97-1.23)0.07
    11-20739/5671.07 (0.94-1.21)
    21-30586/4250.97 (0.85-1.12)
    ≥31645/6231.09 (0.95-1.24)
Age at initiation
    ≤151,283/9711.10 (0.99-1.22)0.45
    16-171,074/8111.07 (0.96-1.19)
    18-191,080/8161.03 (0.92-1.14)
    ≥201,524/1,1571.08 (0.98-1.19)
Intensity (cigarettes/d)
    1-101,623/1,1461.02 (0.93-1.12)0.21
    11-201,908/1,4711.12 (1.02-1.22)
    21-30588/5051.19 (1.04-1.36)
    ≥31567/4421.07 (0.93-1.23)
Duration (y)
    1-10985/5940.94 (0.84-1.06)<0.01
    11-201,085/7171.02 (0.91-1.13)
    21-351,527/1,2331.12 (1.02-1.23)
    ≥361,349/1,1971.16 (1.05-1.28)
Pack-years
    1-101,607/1,0570.99 (0.90-1.08)0.01
    11-20919/6531.04 (0.93-1.17)
    21-35945/7681.14 (1.02-1.27)
    ≥361,194/1,0661.21 (1.09-1.34)
  • * ORs and 95% CIs were estimated using joint fixed-effects logistic regression models, adjusted for study center, age, sex, and race.

  • P for linear trend among smokers only (excludes nonsmokers).