Relative percent content of various fatty acids in RBC membranes of skin SCC cases and controls
| Fatty acid | Cases, n = 336, mean (SE)* | Controls, n = 321, mean (SE)* | P† | OR‡ (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|
| Saturated fatty acids | ||||||||
| 16:0 (palmitic) | 26.799 (.172) | 27.243 (.172) | 0.063 | 0.94 (0.89-1.00) | ||||
| 18:0 (stearic) | 17.453 (.147) | 17.410 (.147) | 0.830 | 1.02 (0.95-1.09) | ||||
| Monounsaturated fatty acids | ||||||||
| 16:1n-7 (palmitoleic) | 0.646 (0.022) | 0.725 (0.023) | 0.011 | 0.49 (0.30-0.81) | ||||
| 18:1n-7c (vacceinic) | 0.715 (0.021) | 0.750 (0.021) | 0.217 | 0.67 (0.41-1.10) | ||||
| 18:1n-9c (oleic-cis) | 17.798 (0.105) | 18.001 (0.106) | 0.160 | 0.96 (0.87-1.06) | ||||
| 18:1n-9t (oleic-trans) | 1.326 (0.039) | 1.375 (0.039) | 0.361 | 0.86 (0.67-1.12) | ||||
| Polyunsaturated fatty acids | ||||||||
| 18:2n-6c (linoleic-cis) | 13.073 (0.106) | 13.034 (0.106) | 0.791 | 1.01 (0.92-1.12) | ||||
| 18:2n-6t (linoleic-trans) | 0.293 (0.017) | 0.336 (0.017) | 0.063 | 0.44 (0.24-0.82) | ||||
| 18:3n-3 (linolenic) | 0.289 (0.020) | 0.304 (0.020) | 0.591 | 0.79 (0.46-1.36) | ||||
| 20:2n-9 (eicosadenoic) | 0.479 (0.027) | 0.476 (0.028) | 0.941 | 1.02 (0.70-1.49) | ||||
| 20:3n-9 (eicosatrienoic) | 1.786 (0.044) | 1.742 (0.044) | 0.465 | 1.04 (0.83-1.31) | ||||
| 20:4n-6 (arachidonic) | 15.301 (0.171) | 14.644 (0.171) | 0.005 | 1.08 (1.02-1.15) | ||||
| Long-chain N-3 polyunsaturated fatty acids | ||||||||
| 20:5n-3 (eicosapentaenoic) | 0.601 (0.030) | 0.606 (0.030) | 0.904 | 0.97 (0.68-1.37) | ||||
| 22:6n-3 (docosahexaenoic) | 3.441 (0.060) | 3.355 (0.060) | 0.301 | 1.12 (0.95-1.33) | ||||
| N3/N6 ratio | 0.1511 (0.002) | 0.1518 (0.002) | 0.840 | 4.57 (1.27-16.49) | ||||
| P/S ratio | 0.8076 (0.008) | 0.7846 (0.008) | 0.046 | 3.00 (0.88-10.18) | ||||
↵* Relative % mean and SE, standardized as weight percentages of the total 14 fatty acids extracted; adjusted for age, sex, lab.
↵† P for t test of difference between adjusted means for cases and controls.
↵‡ OR and 95% CI adjusted for age, sex, lab, freckles on arm, ability to tan, and history of actinic keratosis.