Table 1.

List of studied genes and polymorphisms

GenePolymorphismVariant phenotype
CYP1A13801T-C (rs4646903)In 3′ untranslated region, linked with increased CYP1A1 inducibility.
2455A-G (rs1048943)Ile462Val amino acid change, Val enzyme has higher inducibility.
CYP2E1−1294C-G (rs3813867)In 5′ untranslated region, predicts higher enzyme levels.
GSTM1NullNo expression.
GSTT1NullNo expression.
GSTM3AGG/- (intron 6 deletion; rs1799735)Generates recognition site for YY1 transcription factor.