Table 1.

Multivariate-adjusted ORs for NQO1 and SOD2 polymorphism genotypes and bladder cancer risk

Total population
Never smokers
Smokers
Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)
SOD2
    Val/Val54/571.0 (reference)10/181.0 (reference)44/391.0 (reference)
    Val/Ala122/1031.4 (0.8-2.2)18/420.9 (0.3-2.3)104/611.7 (1.0-2.9)
    Ala/Ala59/541.4 (0.8-2.6)12/191.3 (0.2-3.9)47/351.2 (0.7-2.3)
    Val/Ala or Ala/Ala181/1571.4 (0.9-2.3)30/611.0 (0.4-2.5)151/961.5 (0.9-2.5)
NQO1
    Pro/Pro156/1501.0 (reference)23/591.0 (reference)133/911.0 (reference)
    Pro/Ser70/581.1 (0.7-1.7)13/191.8 (0.7-4.5)57/390.9 (0.5-1.6)
    Ser/Ser9/61.4 (0.5-4.4)3/18.0 (0.7-91.2)6/50.7 (0.2-2.5)
    Pro/Ser or Ser/Ser79/641.1 (0.7-1.7)16/202.1 (0.9-5.1)63/440.9 (0.5-1.5)
  • NOTE: Multivariate models included age (continuous variable), sex (female, male), race (White, other), and smoking (duration in 10-year categories, when possible).