Table 2.

Proportion of variance (R2) in PON1 activity explained by genotypes and haplotypes

GroupArylesterase activity
R2 for PON1 activity
Mean (units/mL)SDGenotypes (−909, −162, −108, 55, 192)*Haplotypes (PON1−909/−162/−108/55/192)
Mothers(N = 396)
All132.433.416.619.3
Caucasian133.131.920.433.4
Hispanic135.835.828.824.9
African-American126.029.39.67.9
Neonates(N = 190)
All38.821.230.935.5
Caucasian29.216.670.460.2
Hispanic38.320.523.630.8
African-American48.422.414.619.7
  • * Genotypes treated as ordinal variables (0,1,2) into the regression model.

  • Common haplotypes (>5% frequency) entered into a regression model; homologous haplotypes recoded to 2; reference group = common haplotype with the highest PON1 activity by group.

  • Adjusted for ethnicity.