Table 3.

Association between Cyp17 genotype, BMI, and breast cancer risk

Cyp17BMI (kg/m2)n casesPerson-years follow-upHR* (95% CI)
A1A1 + A1A2<259345,2951.0
A1A1 + A1A2≥2519874,2141.27 (0.86-1.88)
A2A2<25125,6420.84 (0.34-2.07)
A2A2≥253212,8361.08 (0.60-1.93)
  • * Adjusted for age at recruitment, parity/age at first full-term pregnancy (<30 years, nulliparous + ≥30 years), age at menopause, oral contraceptives use (never/ever), hormonal replacement therapy use, (never/ever), smoking (never/ever), and familial breast cancer (yes/no).