Table 2.

Breast cancer RR in relation to Cyp17 genotype

Genotypen casesPerson-years follow-up*IncidenceRR unadjusted (95% CI)RR adjusted (95% CI)
A1A115161,379.122.461.01.0
A1A214058,129.452.410.96 (0.69-1.33)0.96 (0.68-1.37)
A2A24418,478.112.380.97 (0.61-1.53)0.80 (0.47-1.35)
Ptrend = 0.83Ptrend = 0.44
Total335137,986.672.43
  • * Follow-up for subcohort controls is weighted with 1/α = 22.28 (α = sampling fraction of 4.5%).

  • Per 1,000 person-years, unadjusted.

  • Adjusted for age at recruitment, BMI (kg/m2) parity/age at first full-term pregnancy (<30 years, nulliparous + ≥30 years), age at menopause, oral contraceptives use (never/ever), hormonal replacement therapy use, (never/ever), smoking (never/ever), and familial breast cancer (yes/no).